In This Article
In This Article
23andMe does test for MTHFR variants. Specifically, they analyze the C677T and A1298C variants. However, precisely how much information you receive depends on your subscription.
Knowing your genetic variants can be helpful, but understanding what these results actually mean for your health is crucial. Letโs clarify exactly what your test covers and how to interpret it responsibly.
23andMe+ Premium provides an official report of MTHFR variants. All 23andMe tests include raw genetic data, allowing you to identify your MTHFR variants manually.
Depending on your subscription, 23andMe offers different insights into your MTHFR status:
Tier | Official MTHFR Report? | Raw SNP Data (rs1801133 & rs1801131)? |
Ancestry + Traits | No | Yes |
Health + Ancestry | No | Yes |
23andMe+ Premium | Yes (From March 2025) | Yes |
To check your own MTHFR variants directly, follow these steps to download your raw DNA file:
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Methylenetetrahydrofolate reductase (MTHFR) is a key regulatory enzyme in folate and homocysteine metabolism. It plays a key role in DNA methylation, which affects immune function, and impacts mood regulation.
While the common MTHFR variants typically don't cause significant health problems, some studies link MTHFR mutations with several conditions, such as:
However, there is still no solid scientific evidence to prove this, as research is still in its infancy.
Common variants (C677T & A1298C) exist in 30 to 50% of the population. They usually cause minor reductions in enzyme function, and most carriers can maintain normal homocysteine levels through diet.
However, rare pathogenic MTHFR variants can cause severe MTHFR deficiency, leading to homocystinuria and reduced enzyme function. This can lead to severe medical conditions and require specific clinical genetic tests beyond consumer DNA testing.
Having a common MTHFR variant doesnโt mean you'll develop health problems, but it can inform decisions about diet and pregnancy-related supplementation.
Testing for MTHFR variants has little clinical significance. While many sources claim MTHFR variants cause various health problems, the scientific community largely disagrees regarding the most common variants.
There are extremely rare MTHFR variants that cause a condition called homocystinuria, but these are very different from the commonly tested ones and far less frequent.
Whether or not to analyze your MTHFR status is a personal decision. Here are some factors to consider:
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