Promethease DNA: What Is It and How Does It Work?
Updated on March 18, 2024
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Promethease DNA: What Is It and How Does It Work?

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Key Takeaways

Promethease DNA is an online service that helps you learn about your genetics and how your genes can affect your health. It can be a helpful tool for people who have already done DNA tests from companies like 23andMe or AncestryDNA.

As a literature retrieval service, Promethease takes all the complicated data you get from those DNA tests and turns it into easy-to-understand reports. These reports tell you things about your genes, your risk for diseases, and traits you might have.

Promethease DNA gives a comprehensive look at your genetic makeup.

How Does Promethease Work?

Promethease takes your raw DNA data file, which you might already have from genetic testing services like 23andMe or AncestryDNA, and uses it to give you detailed genetic reports. It works as follows:

  1. Upload your raw DNA data – Upload your data to the Promethease platform. This raw DNA data file contains lots of genetic information, and Promethease helps you make sense of it.
  2. Genetic analysis – Promethease scans your genetic information to identify specific gene variants and markers.
  3. Generate personal reports – It compiles all genetic data into personalized reports. These detailed reports reveal your genetic predispositions to various medical conditions and traits.
  4. Find magnitude scores – Promethease assigns a magnitude score to each genetic variant it identifies. This score tells you how important or significant that variant affects your health. It helps you prioritize what to pay more attention to.
  5. Customize and explore reports – Interact with your reports in various ways. Search for specific genes, traits, or conditions. The health reports are customizable, so you can filter and search for information that interests you the most.

Since some of the health-related genetic findings can be complex, Promethease encourages users to consult with healthcare professionals for better understanding and guidance.

Reading Your Raw DNA Data: The Science Behind Promethease

Promethease reads and interprets raw DNA data by focusing on specific genetic elements, such as single nucleotide polymorphisms (SNPs).

Promethease DNA: What Is It and How Does It Work? 1
Photo Source: Promethease

After a user uploads raw DNA data obtained from genetic services like 23andMe or AncestryDNA, Promethease looks into SNPs.

SNPs are variations in a single nucleotide, which is the building block of DNA, at a specific position in the genome.1 The variations can be as simple as a single-letter change in the DNA sequence.

Promethease compares the SNPs found in the user’s raw DNA data with the entries in its huge database. When it identifies a match, it knows that the user has a specific genetic variant.

The identified genetic variants are compiled into a report that gives detailed insights, covering aspects such as genetic health risks, traits, and more.

Understanding Promethease Reports

Understanding interpreting Promethease reports can be tricky. Here’s how you do it:

  1. Access your reports – Do this by clicking on the link sent to you after uploading your raw DNA data and paying the processing fee.
  2. Check the overview – Your personal DNA report will contain a list of genetic variants found in your DNA. Each variant is linked to a health condition or trait.
  3. Learn about variants and SNPs – Promethease reports are organized by the variants’ IDs, which are usually in the format “rsXXXXX.”
  4. Find information on “Repute” and “Magnitude” – The “Repute” tells whether the variant has a positive, negative, or neutral impact on health. The “Magnitude” indicates the potential significance of the genetic variant.
  5. Learn about color coding – Promethease uses color coding to help users quickly identify the potential impact of each variant. Here’s what the colors mean:
    1. Green – It indicates variants linked with positive or neutral effects on health. These are often considered less concerning.
    2. Yellow – It is used for variants with mixed or unclear effects. It tells that more research is needed to determine the variant’s significance.
    3. Red – It is related to variants that have potential negative effects or health risks. These may be of more concern.

Promethease provides valuable information. Still, this tool doesn’t replace professional medical advice.

If you have concerns about any specific genetic variant or its implications for your health, talk to your healthcare provider, who knows more about your medical history.

How Do You Use Promethease DNA?

Using Promethease DNA is easy. You just need to provide your raw DNA data, which will return information to help you make better decisions for your health.

Uploading DNA Data to Promethease

Uploading your raw DNA data to Promethease is a straightforward process. Follow the steps below to ensure you do it correctly.

1. Gather Your Data

Before uploading your DNA data to Promethease, you must have the raw data file from a genetic testing service like 23andMe, AncestryDNA, or others.

Download your raw data file from your DNA testing service. The file is available for download in your account settings.

2. Go to the Promethease Website

Open your web browser and go to the Promethease website.

3. Accept the Terms and Conditions

On the Promethease website, the first thing you will see are the terms and conditions.

Carefully review before accepting these terms.

The terms and conditions include statements acknowledging the risk of learning about potential health conditions and the importance of consulting a healthcare professional for a better understanding of your results.

4. Upload Your Data

Click “Import from URL” or “Upload Raw Data” to start the process.

You’ll typically be prompted to select the raw data file you downloaded in Step 1. Follow the on-screen instructions to initiate the upload.

Here are some common troubleshooting tips during upload:

  • Verify that you’re using the correct raw data file. Double-check that you’ve downloaded the raw DNA data from your genetic testing service.
  • Some users may encounter issues if their raw data file is in a compressed format (e.g., ZIP or GZIP). If so, you may need to extract the raw data file.
  • Check that your internet connection is stable. A slow or intermittent connection may lead to issues during the upload process.
  • If you receive an error message during the upload, check for specific guidance provided by Promethease on how to resolve the issue. The error message may contain helpful information for troubleshooting.
  • Be patient. Uploading and processing DNA data may take some time. Promethease can generate reports within 15 minutes, but it can also vary depending on the platform’s current workload.
5. Pay the Processing Fee

After uploading the raw DNA data, pay the processing fee of $12 for the full report.

6. Wait for the Promethease Report

This typically takes around 15 minutes. You will receive a link to the results in your email.

7. Explore Your Report

Once you receive the email with the link to your report, click on it to access your Promethease report.

Your report will contain a list of genetic variants found in your DNA, each associated with specific health conditions, traits, or characteristics.

Activating and Utilizing Your DNA Test Results

Take the time to go through your Promethease report carefully. It’s filled with detailed information that can help you make better decisions about your health.

Pay attention to the magnitude score associated with each variant in your report.

This score can tell you of the potential impact of a genetic variant on your health. Higher magnitude scores suggest greater significance.

Promethease DNA: What Is It and How Does It Work? 2
Photo Source: Unsplash

If there’s something specific you’re interested in, explore it more by using the search function on Promethease.

If you come across genetic variants that you find particularly concerning or confusing, consult a medical professional. They can provide expert guidance and help you interpret the results.

Some genetic variants may affect your family members as well. Consider discussing your findings with close relatives who may benefit from the information.

Genetic research is continually evolving. Periodically re-upload your DNA data to Promethease to access updated reports. This keeps you informed about the latest scientific discoveries related to your genetic data.

Using Promethease with AncestryDNA and 23andMe

Using Promethease with services like AncestryDNA and 23andMe is a user-friendly process. It lets you get a better understanding of genetic data you already have through other DNA testing companies.

Information from a genetic test company is a good place to start. However, interpreting the raw data is crucial to get a better picture of your genetics and how it can impact your health.

Here’s how it works:

  • As discussed previously, you begin by uploading your raw DNA data that came from services like AncestryDNA and 23andMe on Promethease DNA.
  • You will get a full report from that.
  • Your Promethease report is divided into sections. Each can give details into your genetic variants and their potential associations with various factors, including health conditions and traits.
  • Take full advantage of Promethease’s search and filtering tools to explore specific aspects of your genetic data.

If you see any results that raise concerns or are difficult to interpret, seek guidance from a genetic counselor or healthcare professional.

Tracing Your Ancestors with Promethease and AncestryDNA

Promethease and AncestryDNA can be used together to get a more complete picture of your genetic heritage and ancestral lineage.

Promethease looks into your DNA more deeply, offering information about your genetic traits and potential health predispositions. On the other hand, AncestryDNA focuses on tracing your ancestral lineage and giving information about your family tree.

AncestryDNA can give you an overview of your ethnic origins and allows you to connect with relatives through its huge genealogical database. You can use it to discover your heritage and connect with long-lost family members.

However, AncestryDNA doesn’t offer extensive details about your genetic traits or potential health risks.

Promethease DNA: What Is It and How Does It Work? 3
Photo Source: Unsplash

This is where Promethease comes in. Using your raw DNA data from AncestryDNA, you can get more information when you upload it on Promethease DNA.

Promethease can shed some light on your genetic present and potential future. It can help you understand if you carry specific genetic variations associated with health conditions, which can be valuable for making proactive healthcare decisions.

AncestryDNA and Promethease can complement each other in your genetic exploration journey.

Together, they offer a bigger view of your genetic identity. They can connect the past and present to empower you with a more comprehensive understanding of your genetic makeup and heritage.

Enhancing Your 23andMe Experience with Promethease

Promethease and 23andMe are a powerful combination that can boost your way toward finding out more about your genetics and health.

23andMe offers informative reports on ancestry composition, DNA relatives, and select health-related traits. Promethease takes this a step further with a deep dive into health and trait analysis.

Promethease’s key advantage is identifying genetic variants linked with specific health conditions. It can empower users to make informed health decisions.

Moreover, Promethease expands trait analysis beyond basic characteristics. It gives details about a larger spectrum of unique traits influenced by genetics.

Promethease’s cost-effectiveness and comprehensive analysis make it a valuable tool for people seeking in-depth genetic insights. It magnifies the information available through 23andMe.

Common Questions About Promethease

Does Promethease show ancestry?

Promethease is primarily geared towards looking into health-related genetic data rather than revealing details about your family history and ancestral roots.

Can Promethease test for specific markers like BRCA1 and BRCA2?

Yes, Promethease can provide information on genetic markers like BRCA1 and BRCA2, which are associated with an increased risk of breast and ovarian cancer.

While Promethease offers information on your genetic predisposition, it’s not a substitute for clinical genetic testing. If you have concerns about specific markers, consult a healthcare professional.

How do I find my haplogroup on Promethease?

Promethease primarily focuses on genetic information relevant to your health and may not provide a detailed analysis of your haplogroup.

To find your haplogroup, consider services like 23andMe or AncestryDNA, which specifically offer ancestry and haplogroup information. These platforms can complement Promethease’s health-related insights.

What is the difference between Promethease and Genomelink?

Promethease and Genomelink offer genetic analysis but differ in their focus.

Promethease offers comprehensive health and trait analysis, providing insights into a wide range of genetic markers.

Meanwhile, Genomelink focuses on specific traits and offers reports on a limited set of genetic markers.

Choosing between the two depends on the genetic information that you seek.

Is Promethease a diagnostic tool or a substitute for medical advice?

No, Promethease is not a diagnostic tool, and it should not be used as a substitute for professional medical advice.

The information it provides is based on genetic associations and should be carefully interpreted. If you have concerns about specific health conditions or genetic markers, consult health care providers for personalized guidance.

Is my genetic data safe with Promethease?

Promethease is committed to data privacy and offers options for data deletion.

If you do not create an account, your DNA data files are automatically deleted after 24 hours. 

Promethease also has a privacy policy that outlines how user data is handled. It’s essential to review their privacy policy to understand how your data is managed.

Updated on March 18, 2024

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1 sources cited
Updated on March 18, 2024
  1. Single Nucleotide Polymorphisms.” National Human Genome Research Institute.
Katrina Canlas
Katrina Canlas
Content Contributor
KC Canlas is an experienced content writer for Know Your DNA. She combines her passion for storytelling with a deep understanding of DNA and genetics. She creates engaging content that can empower readers with knowledge about their genetic makeup, promoting a greater understanding of the role DNA plays in their lives.