Understanding MTHFR and 23andMe Testing

23andMe does not offer an MTHFR-specific health report.

This is because current scientific research doesn’t support the idea that common MTHFR gene variants majorly impact most health conditions they’re often associated with. However, their testing does include some MTHFR variants, so you have other options:

• Raw Data – You can download your raw genetic data from 23andMe
• Third-Party Analysis – Services like Xcode Life or Genetic Genie can analyze your raw 23andMe data and provide a report specifically focused on MTHFR variants, including common ones like C677T and A1298C

What is MTHFR?

Methylenetetrahydrofolate reductase (MTHFR) is a key regulatory enzyme in folate and homocysteine metabolism. It plays a key role in methylation, a process that repairs DNA, affects immune function, and impacts mood regulation.

There are some studies that link MTHFR mutations with several conditions, such as:

• Schizophrenia
• Bipolar disorder
• Depression
• Autism
• Neural tube defects
• Cardiovascular problems

There’s still no solid scientific evidence to prove this, however, as research is still in its infancy.

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What to Consider About MTHFR

• Limited Clinical Significance – While many sources claim MTHFR variants cause various health problems, the scientific community largely disagrees when it comes to the most common variants
• Rare Exceptions – There are extremely rare MTHFR variants that cause a condition called homocystinuria, but these are very different from the commonly tested ones and far less frequent

Should You Get Tested?

Whether or not to analyze your MTHFR status is a personal decision. Here are some factors to consider:

• Family History – Do you have a family history of conditions sometimes linked to MTHFR (neural tube defects, cardiovascular issues, etc.)?
• Consultation – Have you contacted a doctor or genetic counselor to assess your situation?

Reason for Testing – Are you seeking diagnostic information about a current health concern, or is your interest more preventative?

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