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Best Supplements for Digestive Problems (2023)
Updated on September 13, 2023
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Best Supplements for Digestive Problems (2023)
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Trillions of good and harmful bacteria inhabit your digestive tract. They make up your gut microbiome or gut microbiota.1

Healthy gut bacteria can inhibit the growth of disease-causing bacteria. They prevent these harmful microbes from taking over your digestive system.

Gut imbalances may lead to digestive health problems.2

Best Supplements for Digestive Problems (2023) 2

Digestive Symptoms as a Sign of Poor Gut Health

Beneficial and harmful bacteria co-exist in your gut. They aid in digestive functions, such as food breakdown and nutrient absorption.

Your gut flora helps digest essential amino acids and vitamins from the foods we eat. Sometimes, they produce nutrients when digesting certain foods.

When harmful bacteria exceed the good bacteria, it causes gut imbalance. Experiencing digestive issues after meals may be a sign of poor gut health.

Some signs of an unhealthy gut include:

  • Frequent bloating or gas
  • Diarrhea
  • Constipation
  • Abdominal pain
  • Stomach discomfort

Digestive supplements can help reduce your digestive symptoms and improve your overall gut health. Here are the best digestive health supplements we recommend for your gut issues:

6 Best Supplements for Digestive Issues

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How Gut Supplements Can Help Your Digestion

Many gut health supplements have probiotics. They are proven to benefit digestion, weight, immunity, and other things about your health.

Probiotics are beneficial bacteria. They’re safe to consume and can survive in your intestine after ingestion.3 

Some examples of these friendly bacteria are Lactobacillus and Bifidobacterium. Good yeasts like Sacchormyces boulardii can also be taken as probiotics.

Probiotic supplements can increase the amount of good gut bacteria. They also keep bad bacteria at healthy levels. 

Probiotics can  prevent gut health problems, such as:4

  • Diarrhea
  • Irritable Bowel Syndrome (IBS)
  • Stomach ulcers

Below, we picked some of the best digestive health supplements you can try.

Best Supplement for Gut Flora Balance — Ombre Probiotics

Price: Starts at $39.99 with one-time-purchase

Ombre Lab is a wellness company with at-home microbiome testing. Their kits can tell if you have inadequate or excessive bacteria strains.

They’ll give a comprehensive digital report that includes your:

  • Bacteria levels
  • Microbiota diversity score
  • Gut score

Ombre goes beyond gut testing — they’ll also provide you with a food plan. It's a personalized food list that helps you naturally improve gut health.

Customized probiotic supplements are also included in their suggestions. They will be tailored to your body’s needs.

Ombre Gut Health Review

Why I like it: Ombre Lab has 8 options for probiotic supplements. Each ready-made blend targets a specific health concern:

  • Healthy Gut — eases stomach discomfort
  • Metabolic Booster — increases your metabolism
  • Endless Energy — boosts your mental and physical vigor
  • Mood Enhancer — keeps you alert and improves your mood
  • Heart Health — reduces inflammation
  • Harmony — promotes healthy reproductive and urinary tract health
  • Restore — helps you combat infections
  • Ultimate Immunity— strengthens your immunity against COVID-19

You can buy these supplements separately, even without taking Ombre’s test. However, we recommend you take Ombre's microbiome test first. 

It guarantees that you get a probiotics targeted to your needs. They use your report to assess the ideal blend for you.

What I don’t like: The Ombre Gut Test may seem pricey for $99. But the cost is reasonable if you want to understand your gut bacteria.

It can also help you learn how to keep them at healthy levels. Read our full review of Ombre Probiotics.

Sale: $20 off

Best Fiber Supplement for Constipation — Colon Broom

Price: About $68.99 a month (30 capsules)

Fiber has many benefits that support a healthy digestion. You can get it from whole plant-based foods like fruits, vegetables, and grains.

You can also get it from a fiber supplement. Adding fibers to your diet can help you avoid constipation.

Colon Broom is a good fiber supplement because aside from helping with constipation, it also helps with an overactive gut.

Colon Broom Review

What I like: Colon Broom has Psyllium husk. This soluble fiber soaks up water as it passes through your digestive system. 

It improves your bowel movement when you’re constipated by softening the stool. This makes them easier to pass.

It can slow down your digestion by absorbing excess water. If your gut is overactive, it can help relieve symptoms of diarrhea or irritable bowel syndrome.

Research shows that psyllium can lower your risk for diabetes and heart disease. It also keeps your blood sugar and cholesterol levels in check.

What I Don’t Like: Daily use of fiber supplements is safe. But there are instances when they cause digestive symptoms. The psyllium in Colon Broom is no exception. 

Signs that you're taking too many soluble fibers include:

  • Bloating
  • Stomach cramps
  • Flatulence

Stick to the recommended dosage (30 grams a day) to avoid side effects. It should be taken 30 minutes before meals with a glass of water.

Best Supplement for Digestion — ONNIT Total Gut Health

Price: Around $75.90 (30 servings)

ONNIT is a company that focuses on total human optimization (THO). They aim to help you achieve your full potential, so you can become healthier overall.

One of the things they’re committed to is optimal gut health. They developed Total Gut Health™ with Probiotics in line with their holistic view.

ONNIT Total Gut Health Review

What I like: Total Gut Health is a complete digestive health supplement. It contains a blend of different ingredients that promote healthy digestion, including:.

  • Prebiotics — sustain the beneficial bacteria in your gut
  • Probiotics — maintain a healthy gut microbiome
  • Digestive enzymes — aid with the ingestion of nutrients
  • Healthy yeasts — ease digestive symptoms
  • Betaine HCl — regulates stomach acids and helps break down food

ONNIT only uses ingredients supported by science. And they claim to provide promising results with Total Gut Health.

People on vegan or keto diets can safely add this gut health supplement to their regimen. The food label says it’s free of caffeine, dairy, and soy.

What I Don’t Like: Total Gut Health is a preformulated dietary supplement and not personalized probiotics

It isn't designed for your needs. And yet it costs more than Ombre's personalized probiotic supplement.

You can try it to ease bloating, gas, diarrhea, and indigestion. But it may not be ideal if you have specific goals, like weight loss or improving focus. 

Read more about ONNIT Total Gut Health here.

Best Supplement for Bloating & Gas — Now Super Enzymes

Price: About $21.99 per month (30 servings)

Now Super Enzymes mimics the effects of the digestive enzymes produced by your body. It’s great for people with digestive enzyme insufficiency.

When you lack these enzymes, your body will have difficulty breaking down food. This can affect your digestion and cause:

  • Abdominal pain
  • Bloating
  • Gas
  • Heartburn

Now Super Enzymes Review

What I Like: It has a mix of ingredients that break down different foods. Each bottle of Now Super Enzymes contains:

  • Major digestive enzymes
  • Betaine hydrochloride (HCl)
  • Ox bile extract
  • Papaya fruit powder
  • Cellulase

Amylase, protease, and lipase are the major enzymes produced by your body. They break down the carbohydrates, proteins, and fats in your food.

Betaine hydrochloride (HCl) helps produce hydrochloric acid. It works with your digestive enzymes to help your body absorb nutrients and eliminate bacteria in food.

Ox bile extract is a good substitute for bile, a pancreatic enzyme that helps turn fats into fatty acids. Doctors recommend animal-based enzymes for people who don’t have enough bile.

Papaya contains papain and chymopapain. Both enzymes digest protein and fight gut inflammation.

Cellulsase is an enzyme produced by your gut bacteria. It breaks down the insoluble fiber in green leafy vegetables (cellulose).

What I Don’t Like: You have to take Now Foods Super Enzymes with every meal.

There’s also not enough evidence linking digestive enzyme supplements to good digestion. However, research suggests they may be helpful in digestive enzyme therapy.5

Best Probiotic for Antibiotic Diarrhea — Renew Life Ultimate Flora

Price: Starts at $10.49 with one-time purchase

Renew Life started its gut wellness company 25 years ago. Since then, they’ve produced a range of gut health supplements.

Their selections include probiotics that restore good bacteria or repair your gut lining. Renew Life Ultimate Flora may be good for people on antibiotic medications.

Renew Life Ultimate Flora Review

What I Like: Antibiotics can disrupt the balance in your gut microbiome. They can deplete the strains of good bacteria while destroying infectious pathogens.

This imbalance may cause diarrhea and increase your risk for Clostridioides difficile infections. 

Renew Life’s Ultimate Flora Probiotic has 6 billion CFUs of S. boulardii. It is a probiotic yeast that helps prevent antibiotic-associated diarrhea (AAD) in children and adults.

In addition, S. boulardii can also protect you from: 

  • Diarrhea caused by C. difficile and rotavirus
  • Helicobacter pylori infections
  • Digestive symptoms as effects of H. pylori treatment

S. boulardii is typically stored in cold temperatures. But Renew Life’s formula allows for extended shelf-life, so you can keep them longer.

Its plant-based ingredients are safe for people with common food sensitivities. This probiotic supplement is gluten-free, soy-free, and dairy-free.

What I Don’t Like: Ultimate Flora only targets a specific concern. It contains a single strain of yeast which works particularly for diarrhea. 

Still, it’s worth keeping a bottle or two just in case you need it. 

Best Supplement for Leaky Gut — Now Probiotic-10

Price: Starts at $19.99

Now Foods is a family-owned company. They have a wide selection of all-natural products that help improve your health, such as essential oils and organic foods.

Among the gut health supplements they offer are:

  • Probiotics
  • Prebiotic Fiber 
  • Digestive Enzymes
  • Fiber Supplements

Now Probiotic-10™ Veg Capsules is one of our favorites because it may help with a leaky gut.

Now Probiotic-10 Review

What I Like: Leaky gut is linked to digestive health issues such as Celiac disease, Crohn's disease, and irritable bowel syndrome (IBS). 

Probiotic-10 is called such because it contains 10 probiotic strains that can remedy a leaky gut. 

Among the strains included in the supplement are:

  • Lactobacillus casei and Lactobacillus plantarum, which reinforce the gut lining. They can reduce symptoms of a leaky gut.
  • Bifidobacterium lactis and Lactobacillus acidophilus, which relieve gut inflammation. They can help ease inflammatory bowel disease.

They have it in 5 billion CFUs, 50 billion CFUs, and 100 billion CFUs strength. 

Now Probiotic-10 is gluten-free, soy-free, and dairy-free. It’s also made in allergen-free environments. This makes it safe for people with food allergies and intolerances.

What I Don't Like: The many options of Now Probiotics can be overwhelming. Choosing which product is right for you can be challenging if you don’t know what you’re looking for.

Other Ways To Improve Your Digestive Symptoms

Besides taking dietary supplements, eating gut-healthy foods will also help you avoid and reduce digestive issues.

Below are some foods you can add to your diet for better gut health:

  • Probiotic foods — provides good bacteria to help balance your gut flora. Fermented foods such as yogurt and kimchi act as natural probiotics.
  • Prebiotic foods — act as food sources for your good gut bacteria. They support the good microbes in your gastrointestinal (GI) tract.
  • Omega-3 Fatty Acids — improves your gut microbiome diversity.6 Examples are salmon, tuna, mackerel, and other fatty fish.

Why You Should Improve Your Digestive Health

Eating a balanced diet of fruits, vegetables, and animal-sourced foods encourages the growth of good bacteria in your gut.

A healthy gut microbiota encourages healthy immune function. They help prepare your body for microbial attacks and inflammation.7
Your GI tract plays an important role in your immunity. Scientists believe that your gut is where your immune system and bacteria from food interact.8

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Updated on September 13, 2023
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8 sources cited
Updated on September 13, 2023
  1. The Microbiome.” Harvard T.H. Chan, School of Public Health.
  2. The Human Gut Microbiome in Health and Disease.” National Center for Biotechnology Information.
  3. Probiotics.” Cleveland Clinic.
  4. Health benefits of taking probiotics.” Harvard Health Publishing.
  5. Digestive Enzymes and Digestive Enzyme Supplements.” John Hopkins Medicine.
  6. Impact of Omega-3 Fatty Acids on the Gut Microbiota.” National Center for Biotechnology Information.
  7. Nutrition and Immunity.” Harvard T.H. Chan, School of Public Health.
  8. The Gut: Where Bacteria and Immune System Meet.” John Hopkins Medicine.
Cristine Santander
Cristine Santander
Content Contributor
Cristine Santander is a content writer for KnowYourDNA. She has a B.S. in Psychology and enjoys writing about health and wellness.
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